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KMID : 1044720120020020066
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Journal of Lifestyle Medicine
2012 Volume.2 No. 2 p.66 ~ p.69
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Pancreatic Beta Cell Proliferation by Insulin and Glucose
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Namkung Jun
Park Sang-Kyu
Kim Ha-Il
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Abstract
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During pathogenesis of type 2 diabetes, pancreatic beta cells proliferate to compensate insulin resistance, followed by beta cell failure with a decrease in beta cell mass. As increasing beta cell mass has been considered as a therapeutic strategy for type 2 diabetes, identification of factors regulating beta cell proliferation becomes a research of interests. Here we briefly review the regulation of beta cell mass by insulin and glucose, which has been known as strong mitogen to induce beta cell proliferation.
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KEYWORD
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Diabetes, Beta cell mass, Insulin, Glucose
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